(S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate

Base Information

• Chemical Name: (S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate
• CAS No.: 1015841-37-8
• Molecular Formula: C₁₉H₂₅NO₆
• Molecular Weight: 363.411
• Mol file: 1015841-37-8.mol

Synonyms:(S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate

Chemical Property of (S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate

There total 1 articles about (S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(3R,4S,5R,6S)-6-isopropyl-3-methyl-2-oxo-8-phenyl-7,9-dioxa-1-azaspiro[4.5]dec-4-yl-acetate (1015841-36-7) → (S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate (1015841-37-8)

Guidance literature:

With DMDO; In acetone; at 0 - 3 ℃; for 18h;

DOI:10.1021/jo7027695

Reference yield: 83.0%

(S)-1-((2R,3S,4R)-3-acetoxy-2-hydroxymethyl-4-methyl-5-oxo-pyrrolidin-2-yl)-2-methylpropyl benzoate (1015841-37-8) → C19H23NO6 (1015841-38-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; water; at 20 ℃; for 2h;

DOI:10.1021/jo7027695

upstream raw materials:

(3R,4S,5R,6S)-6-isopropyl-3-methyl-2-oxo-8-phenyl-7,9-dioxa-1-azaspiro[4.5]dec-4-yl-acetate

Downstream raw materials:

C₁₉H₂₃NO₆