N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide

Base Information

Chemical Name:N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide
CAS No.:1268685-11-5
Molecular Formula:C₂₂H₂₉NO₃
Molecular Weight:355.477
Hs Code.:

Synonyms:N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide

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Chemical Property of N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide

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Technology Process of N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide

There total 4 articles about N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1268685-02-4
(S)-N-benzyl-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-en-1-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1268685-11-5
N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1016/j.tetlet.2010.12.020

Reference yield:

: 1333213-22-1
C₁₆H₂₁NO₂

: 1268685-11-5
N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: cerium(III) chloride heptahydrate; zinc / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.25 h / 0 °C

With cerium(III) chloride heptahydrate; triethylamine; zinc; In tetrahydrofuran; dichloromethane; 1: Barbier reaction;
DOI:10.1016/j.tetlet.2010.12.020

Reference yield:

: 100-46-9
benzylamine

: 1268685-11-5
N-((S)-1-((S)-1,4-dioxaspiro[4.5]decan-2-yl)but-3-enyl)-N-benzylacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium sulfate / diethyl ether / 0.5 h / 0 °C

2: cerium(III) chloride heptahydrate; zinc / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.25 h / 0 °C

With cerium(III) chloride heptahydrate; magnesium sulfate; triethylamine; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; 2: Barbier reaction;
DOI:10.1016/j.tetlet.2010.12.020