ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Name:ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS No.:1065082-65-6
Molecular Formula:C₁₈H₁₅ClF₃N₃O₃
Molecular Weight:413.784
Hs Code.:

Synonyms:ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Property of ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

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Technology Process of ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

There total 2 articles about ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065082-63-4
2-[4-chloro-3-(trifluoromethoxy)benzyl]butane-1,3-diol

: 6994-25-8,103259-35-4,19750-02-8
3-amino-4-pyrazolecarboxylic acid ethyl ester

: 1065082-65-6
ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: 2-[4-chloro-3-(trifluoromethoxy)benzyl]butane-1,3-diol; With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; for 0.583333h; Cooling with acetone-dry ice;

With triethylamine; In tetrahydrofuran; dichloromethane;

3-amino-4-pyrazolecarboxylic acid ethyl ester; With hydrogenchloride; more than 3 stages;

Reference yield:

: 886500-93-2
(4-chloro-3-trifluoromethoxy)benzyl bromide

: 1065082-65-6
ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 1 h / 65 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.2: 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / tetrahydrofuran; dichloromethane / 0.58 h / Cooling with acetone-dry ice

With lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1065082-65-6
ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

: 1065082-70-3
6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Guidance literature:: ethyl 6-[4-chloro-3-(trifluoromethoxy)benzyl]-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate; With potassium hydroxide; ethanol; water; for 1h; Heating / reflux;

With hydrogenchloride; water; In ethanol;