(3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile

Base Information

Chemical Name:(3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile
CAS No.:828919-77-3
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:(3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile

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Chemical Property of (3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile

Chemical Property:

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Technology Process of (3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile

There total 1 articles about (3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141333-36-0
4-cyanomethyl-2-cyclopentyloxy-1-methoxybenzene

: 828919-77-3
(3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 percent / NaHMDS / tetrahydrofuran / -78 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: PPh₃ / CH₂Cl₂ / -78 °C

With sodium hexamethyldisilazane; ozone; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.12.018

Reference yield:

: 828919-77-3
(3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile

: 828919-96-6
[(1R,2S)-2-Carboxymethyl-4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclopentyl]-acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol;
DOI:10.1016/j.bmcl.2003.12.018

Reference yield:

: 828919-77-3
(3S,4R)-1-(3-Cyclopentyloxy-4-methoxy-phenyl)-3,4-bis-(2-oxo-ethyl)-cyclopentanecarbonitrile

: 439919-54-7
(2s,3aR,6aS)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 3 h / 20 °C

2.1: 2.66 g / diethyl ether / 0 °C

3.1: NaH / 1,2-dimethoxy-ethane / 1.5 h / Heating

3.2: 48 percent / NaCl; H₂O / dimethylsulfoxide / 1 h / 165 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydride; In 1,2-dimethoxyethane; diethyl ether; water; tert-butyl alcohol; 3.1: Dieckmann condensation;
DOI:10.1016/j.ejmech.2004.02.010