1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene

Base Information

Chemical Name:1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene
CAS No.:130893-28-6
Molecular Formula:C₃₀H₄₀O₄
Molecular Weight:464.645
Hs Code.:

Synonyms:1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene

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Technology Process of 1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene

There total 1 articles about 1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 125112-04-1,125224-90-0,130980-47-1
1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11(S)-hydroxy-octadecadi-9,15-yn-12-ene

: 65-85-0,8013-63-6
benzoic acid

: 130893-28-6
1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1016/S0040-4020(01)87778-4

Reference yield:

: 130893-28-6
1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene

: 125112-06-3
(-)-(11S,12S,13S)-11-p-Bromobenzoyloxy-12,13-epoxyoctadecadi-9,15-yn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / 1N KOH / methanol / 2 h / Ambient temperature

2: 90 percent / TIP, (+)-DIPT, TBHP

3: 74 percent / NEt₃ / DMAP / CH₂Cl₂ / 2 h / Ambient temperature

4: 80 percent / PPTS / ethanol / 0.5 h / Heating

With tert.-butylhydroperoxide; potassium hydroxide; L-(+)-diisopropyl tartrate; isobutyltriphenylphosphonium bromide; triethylamine; dmap; pyridinium p-toluenesulfonate; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)87778-4

Reference yield:

: 130893-28-6
1-<(Tetrahydro-2H-pyran-2-yl)oxy>-11-benzoyloxyoctadecadi-9,15-yn-12-ene

: 130893-27-5
4-Bromo-benzoic acid (S)-11-oxo-1-((2S,3S)-3-pent-2-ynyl-oxiranyl)-undec-2-ynyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / 1N KOH / methanol / 2 h / Ambient temperature

2: 90 percent / TIP, (+)-DIPT, TBHP

3: 74 percent / NEt₃ / DMAP / CH₂Cl₂ / 2 h / Ambient temperature

4: 80 percent / PPTS / ethanol / 0.5 h / Heating

5: PCC, NaOAc / CH₂Cl₂ / 2 h

With tert.-butylhydroperoxide; potassium hydroxide; L-(+)-diisopropyl tartrate; sodium acetate; isobutyltriphenylphosphonium bromide; triethylamine; pyridinium chlorochromate; dmap; pyridinium p-toluenesulfonate; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)87778-4