4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

Base Information

Chemical Name:4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine
CAS No.:237436-84-9
Molecular Formula:C₁₇H₁₆F₂N₄O
Molecular Weight:330.337
Hs Code.:

Synonyms:4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

Suppliers and Price of 4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

Chemical Property:

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Technology Process of 4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

There total 3 articles about 4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 13162-43-1
4,6-dichloro-2-methyl-5-nitropyrimidine

: [1-(3,4-difluorophenyl)vinyl]pyrrolidine

: 237436-84-9
4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

Guidance literature:: With stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine; TiCl₄; In N,N-dimethyl-formamide;

Reference yield:

: 1194-22-5
2-methyl-4,6-dihydroxypyrimidine

: 237436-84-9
4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: nitric acid; trifluoroacetic acid / water

2: trichlorophosphate / n-heptane; toluene

3: stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine / TiCl₄ / N,N-dimethyl-formamide

With nitric acid; stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; TiCl₄; In n-heptane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 53925-27-2
2-methyl-4,6-dihydroxy-5-nitropyrimidine

: 237436-84-9
4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / n-heptane; toluene

2: stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine / TiCl₄ / N,N-dimethyl-formamide

With stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; TiCl₄; In n-heptane; N,N-dimethyl-formamide; toluene;