<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide

Base Information

Chemical Name:<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide
CAS No.:122253-42-3
Molecular Formula:Br*C₃₂H₂₈FNP
Molecular Weight:556.457
Hs Code.:

Synonyms:<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide

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Chemical Property of <2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide

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Technology Process of <2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide

There total 5 articles about <2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 122253-19-4
bromo<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methane

: 603-35-0
triphenylphosphine

: 122253-42-3
<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide

Guidance literature:: In toluene; for 5h; Heating;
DOI:10.1021/jm00163a010

Reference yield:

: 65300-29-0,1611-38-7
4-(4-fluorophenyl)but-3-en-2-one

: 122253-42-3
<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / KOH, EtOH / diethyl ether / 3 h

2: 91 percent / ammonium acetate, FCl₃*6H₂O / acetic acid / 4 h / Heating

3: 93 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

4: 79 percent / PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

5: 89 percent / toluene / 5 h / Heating

With ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; ethanol; phosphorus tribromide; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1021/jm00163a010

Reference yield:

: 122252-96-4
2,6-Dimethyl-4-(4-fluorophenyl)-3-hydroxymethyl-pyridine

: 122253-42-3
<2,6-dimethyl-4-(4-fluorophenyl)pyridin-3-yl>methyltriphenylphosphonium bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

2: 89 percent / toluene / 5 h / Heating

With phosphorus tribromide; In dichloromethane; toluene;
DOI:10.1021/jm00163a010