ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate

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Chemical Name:ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate
CAS No.:957130-76-6
Molecular Formula:C₁₆H₁₆ClN₃O₃S
Molecular Weight:365.84
Hs Code.:

Synonyms:ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate

There total 1 articles about ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 3289-75-6
2-chloro-N-(4-chlorophenyl)acetamide

: ethyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate hydrochloride

: 957130-76-6
ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:: With sulfur; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1134/S1070428007050181

Reference yield:

: 957130-76-6
ethyl 4-({2-[(4-chlorophenyl)amino]-2-oxoethanethioyl}amino)-1-methyl-1H-pyrrole-2-carboxylate

: 3-anilino-4-(2,4,5-trimethyl-4H-pyrrolo[3,2-d][1,3]thiazol-6-yl)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOH / H₂O

1.2: 90 percent / K₃[Fe(CN)6] / H₂O / 24 h

2.1: 96 percent / diethyl ether; tetrahydrofuran / 1 °C

3.1: 87 percent / AlCl₃; LiAlH₄ / tetrahydrofuran / 2 h

4.1: 65 percent / AlCl₃ / 1,2-dichloro-ethane; heptane / 5 h

5.1: 95 percent / tetrahydrofuran / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; diethyl ether; n-heptane; water; 1,2-dichloro-ethane;
DOI:10.1134/S1070428007050181