C₄₇H₆₉O₁₂P

Base Information

• Chemical Name: C₄₇H₆₉O₁₂P
• CAS No.: 207981-83-7
• Molecular Formula: C₄₇H₆₉O₁₂P
• Molecular Weight: 857.031
• Mol file: 207981-83-7.mol

Synonyms:C₄₇H₆₉O₁₂P

Chemical Property of C₄₇H₆₉O₁₂P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₆₉O₁₂P

There total 14 articles about C₄₇H₆₉O₁₂P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C50H73O12P (207981-81-5) → C47H69O12P (207981-83-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; ethylene glycol;

DOI:10.1016/S0040-4039(98)00418-3

Reference yield:

1,12-dibromododecane (3344-70-5) → C47H69O12P (207981-83-7)

Guidance literature:

Multi-step reaction with 12 steps

1: 1.) di-n-butyltin oxide; 2.) CsF / 1.) MeOH; 2.) DMF, rt.

2: 90 percent / DMAP / pyridine

3: 86 percent / ceric ammonium nitrate / acetonitrile; H₂O

4: 80 percent / K₂CO₃ / methanol

5: 100 percent / p-TsOH

6: 83 percent / K₂CO₃ / dimethylformamide / Ambient temperature

7: 82 percent / p-TsOH / CH₂Cl₂

8: 86 percent / imidazole / dimethylformamide / Ambient temperature

9: 100 percent / DMAP / pyridine; CH₂Cl₂ / Ambient temperature

10: 96 percent / HCl / H₂O; ethanol / 1 h / Ambient temperature

11: 85 percent / NPCl / pyridine / 0.25 h / Ambient temperature

12: 67 percent / PPTS / ethane-1,2-diol; CH₂Cl₂

With 1H-imidazole; hydrogenchloride; dmap; ammonium cerium(IV) nitrate; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; potassium carbonate; toluene-4-sulfonic acid; cesium fluoride; In pyridine; methanol; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(98)00418-3

Reference yield:

(R)-1-(12-Bromo-dodecyloxy)-3-(4-methoxy-phenoxy)-propan-2-ol (207981-71-3) → C47H69O12P (207981-83-7)

Guidance literature:

Multi-step reaction with 11 steps

1: 90 percent / DMAP / pyridine

2: 86 percent / ceric ammonium nitrate / acetonitrile; H₂O

3: 80 percent / K₂CO₃ / methanol

4: 100 percent / p-TsOH

5: 83 percent / K₂CO₃ / dimethylformamide / Ambient temperature

6: 82 percent / p-TsOH / CH₂Cl₂

7: 86 percent / imidazole / dimethylformamide / Ambient temperature

8: 100 percent / DMAP / pyridine; CH₂Cl₂ / Ambient temperature

9: 96 percent / HCl / H₂O; ethanol / 1 h / Ambient temperature

10: 85 percent / NPCl / pyridine / 0.25 h / Ambient temperature

11: 67 percent / PPTS / ethane-1,2-diol; CH₂Cl₂

With 1H-imidazole; hydrogenchloride; dmap; ammonium cerium(IV) nitrate; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; In pyridine; methanol; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(98)00418-3

upstream raw materials:

C₅₀H₇₃O₁₂P

1,12-dibromododecane

(3aS,4S,5S,5aR,8aS,8bS)-5-Benzyloxy-2,2,7,7-tetramethyl-hexahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-4-ol

1-O-(12-bromododecyl)-sn-glycerol

Downstream raw materials:

Hexanoic acid (R)-2-{[(3aR,4S,5S,6R,7R,7aS)-5-benzyloxy-6,7-bis-(bis-benzyloxy-phosphoryloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-4-yloxy]-hydroxy-phosphoryloxy}-1-[12-(naphthalen-2-yloxy)-dodecyloxymethyl]-ethyl ester

C₇₅H₉₅O₁₈P₃