Technology Process of 4-Chlor-2-fluor-5-sulfamoylanilin
There total 7 articles about 4-Chlor-2-fluor-5-sulfamoylanilin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
for 1h;
Ambient temperature;
DOI:10.1021/jm00362a017
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaNO2, HCl, 2.) CuCl2*2H2O, HOAc, SO2 / 1.) H2O, 2.) H2O, RT
2: 90 percent / NH3 / Ambient temperature
3: 87 percent / dimethylformamide / 30 h / 60 °C
4: 94 percent / fuming sulfuric acid (20percent SO2), fuming HNO3 / 2 h / 55 °C
5: 90 percent / H2 / 5percent Pd/C / tetrahydrofuran / 20 °C / 75.01 Torr
6: 91 percent / 2N aq. NaOH / methanol / 1 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; sulfuric acid; sulfur dioxide; sulfur trioxide; ammonia; hydrogen; nitric acid; acetic acid; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00362a017
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 94 percent / fuming sulfuric acid (20percent SO2), fuming HNO3 / 2 h / 55 °C
2: 90 percent / H2 / 5percent Pd/C / tetrahydrofuran / 20 °C / 75.01 Torr
3: 91 percent / 2N aq. NaOH / methanol / 1 h / Ambient temperature
With
sodium hydroxide; sulfuric acid; sulfur trioxide; hydrogen; nitric acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
DOI:10.1021/jm00362a017
