(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone

Base Information

Chemical Name:(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone
CAS No.:1290053-86-9
Molecular Formula:C₂₅H₃₂N₂O₄
Molecular Weight:424.54
Hs Code.:

Synonyms:(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone

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Chemical Property of (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone

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Technology Process of (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone

There total 6 articles about (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1290056-80-2
tert-butyl N-[[3-[1-[3-[2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

: 1290053-86-9
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; for 5h;
DOI:10.1021/acsmedchemlett.8b00204

Reference yield:

: 27741-65-7
α-(ethoxycarbonyl)methylenecyclobutane

: 1290053-86-9
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / -20 °C

2.2: -20 - 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

5.1: osmium(VIII) oxide / water; acetone / 0.17 h / 20 °C

5.2: 15 h / 20 °C

6.1: hydrogenchloride / water; methanol / 5 h / 20 °C

With hydrogenchloride; osmium(VIII) oxide; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
DOI:10.1021/acsmedchemlett.8b00204

Reference yield:

: 4415-76-3
α-(hydroxymethyl)methylenecyclobutane

: 1290053-86-9
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / -20 °C

1.2: -20 - 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

4.1: osmium(VIII) oxide / water; acetone / 0.17 h / 20 °C

4.2: 15 h / 20 °C

5.1: hydrogenchloride / water; methanol / 5 h / 20 °C

With hydrogenchloride; osmium(VIII) oxide; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/acsmedchemlett.8b00204