Chemical Property of Jacaric acid
Chemical Property:
- PSA：37.30000
- LogP:5.66050
- Storage Temp.:-20°C, Light sensitive
- Solubility.:Ethanol (Soluble)
- XLogP3:6.7
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:13
- Exact Mass:278.224580195
- Heavy Atom Count:20
- Complexity:301
- Purity/Quality:
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≥95% *data from raw suppliers
JacaricAcid *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCC=CC=CC=CCCCCCCC(=O)O
- Isomeric SMILES:CCCCC/C=C\C=C\C=C/CCCCCCC(=O)O
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Description
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 μM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.
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Uses
8(Z),10(E),12(Z)-Octadecatrienoic Acid, is a conjugated Linoleic Acid, a compound that has reported to exhibit anticarcinogenic activity. Also a potent antioxidant. Jacaric Acid (10mg/mL in Ethanol) is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.
