(1aS,8R,9R,9aS)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

Base Information

Chemical Name:(1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine
CAS No.:129077-33-4
Molecular Formula:C₄₂H₄₄N₂O₈S₂
Molecular Weight:768.952
Hs Code.:

Synonyms:(1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

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Chemical Property of (1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

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Technology Process of (1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

There total 1 articles about (1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 129056-06-0
(3aR*,4R*,11R*,11aR*)-7,10-dibenzyloxy-4-iodo-9-methoxy-8,11-dimethyl-2-oxo-3,6-bis(p-toluenesulfonyl)-2,3,3a,4,5,6,11,11a-octahydrooxazolo<4,5-d><1>benzazocine

: 129077-33-4
(1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

Guidance literature:: With potassium carbonate; In methanol; dichloromethane; at 35 - 40 ℃; for 3h;
DOI:10.1039/c39900000468

Reference yield: 100.0%

: 129077-33-4
(1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

: 129056-07-1
(1aS*,8R*,9aS*)-4,7-dibenzyloxy-6-methoxy-5,8-dimethyl-9-oxo-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1039/c39900000468

Reference yield:

: 129077-33-4
(1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

: 129056-08-2
(1aS*,8R*,8aR*,8bS*)-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-4,7-dioxo-1-p-toluenesulfonyl-1,1a,2,4,7,8,8a,8b-octahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / PCC, molecular sieves 4A / CH₂Cl₂ / 35 h / Ambient temperature

2: 100 percent / Et₃N / CH₂Cl₂ / 0.17 h / Ambient temperature

3: H₂ / 10percent Pd/C / ethyl acetate / 0.17 h / Ambient temperature

4: O₂ / ethyl acetate / 0.17 h / Ambient temperature

With 4 A molecular sieve; hydrogen; oxygen; triethylamine; pyridinium chlorochromate; palladium on activated charcoal; In dichloromethane; ethyl acetate;