(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid

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Chemical Name:(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid
CAS No.:586968-79-8
Molecular Formula:C₃₅H₄₂IN₃O₈
Molecular Weight:759.638
Hs Code.:

Synonyms:(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid

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Chemical Property of (S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid

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Technology Process of (S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid

There total 1 articles about (S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid methyl ester

: 586968-79-8
(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1021/ol034801t

Reference yield: 86.0%

: 2491-20-5
L-alanine methyl ester hydrochloride

: 586968-79-8
(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid

: 586968-66-3
(S)-2-[(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionylamino]-propionic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃;
DOI:10.1021/ol034801t

Reference yield:

: 586968-79-8
(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-(4-benzyloxy-3-iodo-phenyl)-propionic acid

: (S)-2-{(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-[4-benzyloxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propionylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / DIPEA; EDCI; HOBt / tetrahydrofuran; acetonitrile / 0 - 20 °C

2: KOAc; PdCl₂dppf / dimethylsulfoxide / 5 h / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile; 2: Miyaura reaction;
DOI:10.1021/ol034801t