4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide
CAS No.:1429291-89-3
Molecular Formula:C₁₆H₁₉Cl₂N₃O₂
Molecular Weight:356.252
Hs Code.:

Synonyms:4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

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Chemical Property of 4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

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Technology Process of 4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

There total 8 articles about 4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.1%

: 1429291-83-7
N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

: 1429291-89-3
4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: With ammonium formate; In ethanol; at 100 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 1429293-40-2
N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-4-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

: 1429291-89-3
4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: boron trichloride / dichloromethane / 4.75 h / 20 °C

2: ammonium formate / ethanol / 1.5 h / 100 °C / Microwave irradiation

With ammonium formate; boron trichloride; In ethanol; dichloromethane;

Reference yield:

: 5336-43-6
ethyl 1-ethyl-4,5-dioxopyrrolidine-3-carboxylate

: 1429291-89-3
4-amino-N-(3-(3,4-dichlorophenyl)propyl)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / diethyl ether; methanol; acetonitrile / 3.5 h / 20 °C

2.1: water; sodium hydroxide / methanol / 1 h / 70 °C

3.1: oxalyl dichloride / dichloromethane / 4 h / 20 °C

3.2: 16 h / 20 °C

4.1: boron trichloride / dichloromethane / 4.75 h / 20 °C

5.1: ammonium formate / ethanol / 1.5 h / 100 °C / Microwave irradiation

With oxalyl dichloride; water; ammonium formate; boron trichloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; acetonitrile;