4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

Base Information

Chemical Name:4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one
CAS No.:874660-55-6
Molecular Formula:C₂₅H₃₂O₆Si
Molecular Weight:456.611
Hs Code.:

4-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-<i>c</i>]pyran-2-one

Synonyms:4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

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Chemical Property of 4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

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Technology Process of 4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

There total 6 articles about 4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 874660-31-8
(2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-pyran-3,4-diol

: 530-62-1
1,1'-carbonyldiimidazole

: 874660-55-6
4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

Guidance literature:: In tetrahydrofuran; for 2.5h; Heating;
DOI:10.1021/ol0526625

Reference yield:

: 874660-54-5
tert-butyl-(6-ethoxy-5,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

: 874660-55-6
4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / sodium periodate; RuCl₃*7H₂O / H₂O; ethyl acetate; acetonitrile / 0.02 h / 0 °C

2: 90 percent / tetrahydrofuran / 2.5 h / Heating

With ruthenium trichloride; sodium periodate; In tetrahydrofuran; water; ethyl acetate; acetonitrile; 2: Hosomi-Sakurai reaction;
DOI:10.1021/ol0526625

Reference yield:

: 874660-28-3
tert-butyl-[2-(1-ethoxy-but-3-enyloxy)-but-3-enyloxy]-diphenyl-silane

: 874660-55-6
4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: (Cy₃P)2Cl₂Ru=CHPh / CH₂Cl₂ / 2.5 h / 40 °C

1.2: 93 percent / CH₂Cl₂; dimethylsulfoxide / 20 °C

2.1: 75 percent / sodium periodate; RuCl₃*7H₂O / H₂O; ethyl acetate; acetonitrile / 0.02 h / 0 °C

3.1: 90 percent / tetrahydrofuran / 2.5 h / Heating

With ruthenium trichloride; sodium periodate; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile; 3.1: Hosomi-Sakurai reaction;
DOI:10.1021/ol0526625