(2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

Base Information

Chemical Name:(2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol
CAS No.:740805-34-9
Molecular Formula:C₁₇H₂₅NO₃
Molecular Weight:291.39
Hs Code.:

Synonyms:(2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

Suppliers and Price of (2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

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Technology Process of (2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

There total 21 articles about (2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 740805-33-8
phenyl (2S,3S,4R,5S)-1-benzyl-5-methyl-3,4-isopropylidenedioxypyrrolidine-2-acetate

: 740805-34-9
(2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 3h;
DOI:10.1016/j.carres.2011.03.030

Reference yield: 72.0%

: 1390639-93-6
C₁₇H₂₃NO₃

: 740805-34-9
(2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

Guidance literature:: With sodium tetrahydroborate; Inert atmosphere;
DOI:10.1039/c2ob25727k

Reference yield:

: 23276-32-6
benzyl 2,3-O-isopropylidene-D-ribofuranoside

: 740805-34-9
(2S,3S,4R,5S)-1-benzyl-3,4-isopropylidenedioxy-5-methylpyrrolidinemethylpyrrolidine-2-ethanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: NEt₃

2.1: AlLiH₄ / diethyl ether

3.1: 96 percent / hydrogen / Pd/C

4.1: 96 percent / NH₂OH

5.1: 67 percent / pyridine

6.1: NEt₃

7.1: NBu₄F; CsF / 20 °C

8.1: 85 percent / tetrachloroethene / 50 °C

9.1: CHCl₃

9.2: 67 percent / CHCl₃ / 50 °C

10.1: 61 percent / LiAlH₄ / diethyl ether

With pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; hydroxylamine; triethylamine; cesium fluoride; palladium on activated charcoal; In 1,1,2,2-tetrachloroethylene; diethyl ether; chloroform; 9.1: Bayon's method;
DOI:10.1016/j.tetlet.2004.05.075