3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel

Base Information

Chemical Name:3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel
CAS No.:205490-32-0
Molecular Formula:C₅₈H₈₁NO₁₆Si
Molecular Weight:1076.36
Hs Code.:

Synonyms:3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel

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Chemical Property of 3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel

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Technology Process of 3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel

There total 2 articles about 3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 148877-81-0
13-deacetylbaccatin VI

: 172213-23-9
(3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-phenylazetidin-2-one

: 205490-32-0
3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 6h;
DOI:10.1021/jo981406l

Reference yield:

: 1β-dehydroxybaccatine VI

: 205490-32-0
3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-7,9-diacetyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / Red-Al / tetrahydrofuran; toluene / 0.33 h / -20 °C

2: 77 percent / NaH / tetrahydrofuran / 6 h / 0 - 20 °C

With sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene;
DOI:10.1021/jo981406l