ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate

Base Information

• Chemical Name: ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate
• CAS No.: 299966-28-2
• Molecular Formula: C₂₁H₂₀FN₃O₃
• Molecular Weight: 381.407

Synonyms:ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate

Chemical Property of ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate

There total 7 articles about ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-acetylpropanoic acid ethyl ester (609-14-3) + 4-(2-fluoro-phenyl)-8-methoxy-quinoline-5-diazonium → ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate (299966-28-2)

Guidance literature:

With potassium hydroxide; sodium acetate; In ethanol; water; at 0 ℃; for 1h;

DOI:10.1021/jo000011a

Reference yield:

o-fluorophenylboronic acid (1993-03-9) → ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate (299966-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / K₂CO₃; Pd(PPh₃)4 / ethanol; toluene / Heating

2: 65 percent / cyclohexene / Pd/C / ethanol / 0.75 h / Heating

3: NaNO₂; aq. HCl / 0.25 h / 0 °C

4: 86 percent / KOH; NaOAc / ethanol; H₂O / 1 h / 0 °C

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; potassium carbonate; cyclohexene; sodium nitrite; palladium on activated charcoal; In ethanol; water; toluene; 1: Condensation / 2: Reduction / 3: Diazotization / 4: Condensation;

DOI:10.1021/jo000011a

Reference yield:

4-Chloro-8-methoxy-5-nitroquinoline (145013-65-6) → ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate (299966-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / K₂CO₃; Pd(PPh₃)4 / ethanol; toluene / Heating

2: 65 percent / cyclohexene / Pd/C / ethanol / 0.75 h / Heating

3: NaNO₂; aq. HCl / 0.25 h / 0 °C

4: 86 percent / KOH; NaOAc / ethanol; H₂O / 1 h / 0 °C

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; potassium carbonate; cyclohexene; sodium nitrite; palladium on activated charcoal; In ethanol; water; toluene; 1: Condensation / 2: Reduction / 3: Diazotization / 4: Condensation;

DOI:10.1021/jo000011a

upstream raw materials:

2-acetylpropanoic acid ethyl ester

o-fluorophenylboronic acid

4-Chloro-8-methoxy-5-nitroquinoline

8-methoxy-5-nitroquinoline-4-one

Downstream raw materials:

ethyl 9-(2'-fluorophenyl)-5-methoxypyrrolo[2,3-f]quinoline-2-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 299966-28-2 ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate

Send

Send

Metric Ton KG G Pound L ML

Send

Send