4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester

Base Information

• Chemical Name: 4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester
• CAS No.: 1161743-37-8
• Molecular Formula: C₁₉H₁₅N₅O₇S
• Molecular Weight: 457.423

Synonyms:4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester

Chemical Property of 4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester

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Technology Process of 4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester

There total 1 articles about 4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

4-(6-amino-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-ylcarbamoyl)benzenesulfonic acid 4-nitrophenyl ester (1161743-34-5) → 4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester (1161743-37-8)

Guidance literature:

With polyphosphoric acid trimethylsilyl ester; at 120 - 170 ℃; for 2.16667h;

DOI:10.1021/jm900413e

Reference yield: 77.0%

1-phenylmethylpiperazine (2759-28-6) + 4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester (1161743-37-8) → 8-(4-(4-benzylpiperazine-1-sulfonyl)phenyl)-1-ethyl-3,7-dihydropurine-2,6-dione (1161743-40-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 49h; Reflux;

DOI:10.1021/jm900413e

Reference yield: 71.0%

piperidine (110-89-4) + 4-(1-ethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid 4-nitrophenyl ester (1161743-37-8) → 1-ethyl-8-(4-(piperidine-1-sulfonyl)phenyl)-3,7-dihydropurine-2,6-dione (1161743-70-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 49h; Reflux;

DOI:10.1021/jm900413e

upstream raw materials:

4-(6-amino-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-ylcarbamoyl)benzenesulfonic acid 4-nitrophenyl ester

Downstream raw materials:

1-ethyl-8-(4-(piperidine-1-sulfonyl)phenyl)-3,7-dihydropurine-2,6-dione

8-(4-(4-benzylpiperazine-1-sulfonyl)phenyl)-1-ethyl-3,7-dihydropurine-2,6-dione

1-ethyl-8-(4-(4-phenethylpiperazine-1-sulfonyl)phenyl)-3,7-dihydropurine-2,6-dione

1-ethyl-8-(4-(4-(4-methylbenzyl)piperazine-1-sulfonyl)phenyl)-3,7-dihydropurine-2,6-dione

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