7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one

Base Information

Chemical Name:7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one
CAS No.:878541-58-3
Molecular Formula:C₂₂H₂₀BrCl₂NO
Molecular Weight:465.217
Hs Code.:

Synonyms:7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one

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Chemical Property of 7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one

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Technology Process of 7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one

There total 8 articles about 7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 878541-58-3
7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one

Guidance literature:

Reference yield:

: 878541-84-5
1-{2-(4-bromobenzyl)-1-[(3,5-dichlorophenyl)acetyl]pyrrolidin-2-yl}propan-1-one

: 878541-58-3
7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one

Guidance literature:: With potassium hydroxide; In methanol; Heating;
DOI:10.1016/j.bmcl.2007.01.036

Reference yield:

: 878541-81-2
1-[2-(4-bromobenzyl)pyrrolidin-2-yl]propan-1-one

: 878541-58-3
7a-(4-Bromobenzyl)-2-(3,5-dichlorophenyl)-1-ethyl-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: EDCI; DIPEA / dimethylformamide

2: KOH / methanol / Heating

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.036