1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidine

Base Information

Chemical Name:1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidine
CAS No.:83409-00-1
Molecular Formula:C₂₄H₂₇N₃O₅
Molecular Weight:437.495
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50232339
Wikidata:Q83113366
Mol file:83409-00-1.mol

Synonyms:83409-00-1;BRN 4597044;1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidine;Piperidine, 1-((4-oxo-2-(3,4,5-triemthoxyphenyl)-3(4H)-quinazolinyl)acetyl)-;DTXSID50232339;LS-115851;1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidin e

Suppliers and Price of 1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(4-OXO-2-(3,4,5-TRIMETHOXYPHENYL-3(4H)-QUINAZOLINYL)ACETYL)PIPERIDIN E 95.00%
5MG
$ 503.20

Total 4 raw suppliers

Chemical Property of 1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidine

Chemical Property:

Vapor Pressure:5.34E-16mmHg at 25°C
Boiling Point:634.4°C at 760 mmHg
Flash Point:337.5°C
PSA：82.89000
Density:1.27g/cm³
LogP:3.03970
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:437.19507097
Heavy Atom Count:32
Complexity:694

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

1-(4-OXO-2-(3,4,5-TRIMETHOXYPHENYL-3(4H)-QUINAZOLINYL)ACETYL)PIPERIDIN E 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2=NC3=CC=CC=C3C(=O)N2CC(=O)N4CCCCC4

Technology Process of 1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidine

There total 5 articles about 1-(4-Oxo-2-(3,4,5-trimethoxyphenyl-3(4H)-quinazolinyl)acetyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 110-89-4
piperidine

: 83409-25-0
[4-Oxo-2-(3,4,5-trimethoxy-phenyl)-4H-quinazolin-3-yl]-acetyl chloride

: 83409-00-1
3-(2-Oxo-2-piperidin-1-yl-ethyl)-2-(3,4,5-trimethoxy-phenyl)-3H-quinazolin-4-one

Guidance literature:: In benzene; for 2h; Heating;

Reference yield:

: 40728-74-3
2-(3,4,5-trimethoxyphenyl)-4-H-benzo[d][1,3]oxazin-4-one

: 83409-00-1
3-(2-Oxo-2-piperidin-1-yl-ethyl)-2-(3,4,5-trimethoxy-phenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / pyridine; H₂O / 10 h / Heating

2: SOCl₂ / benzene / 6 h / Heating

3: 75 percent / benzene / 2 h / Heating

With thionyl chloride; In pyridine; water; benzene;

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 83409-00-1
3-(2-Oxo-2-piperidin-1-yl-ethyl)-2-(3,4,5-trimethoxy-phenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 1) 0-5 deg C 2) 1h, room temperature

2: 85 percent / pyridine; H₂O / 10 h / Heating

3: SOCl₂ / benzene / 6 h / Heating

4: 75 percent / benzene / 2 h / Heating

With pyridine; thionyl chloride; In pyridine; water; benzene;