2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene

Base Information

Chemical Name:2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene
CAS No.:139219-32-2
Molecular Formula:C₂₃H₂₁BrO₅
Molecular Weight:460.297
Hs Code.:

2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d<sub>3</sub>)-3-(phenylethynyl)naphthalene

Synonyms:2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene

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Chemical Property of 2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene

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Technology Process of 2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene

There total 3 articles about 2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 7575-93-1
methyl-d3 4-methylbenzenesulfonate

: 139219-31-1
3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenol

: 139219-32-2
2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 2.5h; Ambient temperature;
DOI:10.1039/c39910001755

Reference yield:

: 139219-30-0
<<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane

: 139219-32-2
2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / Bu₄NF, AcOH / tetrahydrofuran / 0.5 h

2: 81 percent / NaH (60percent in oil) / dimethylformamide / 2.5 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium hydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88016-9

Reference yield:

: 2-bromo-5,6,8-trimethoxy-3-(phenylethynyl)-4-<(triethylsilyl)oxy>-1-naphthalenol

: 139219-32-2
2-bromo-1,5,6,8-tetramethoxy-4-(methoxy-d₃)-3-(phenylethynyl)naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Na₂S₂O₄, Bu₄NBr, 2) 2N NaOH / 1) H₂O, CH₂Cl₂, 30 min, RT, 2) H₂O, CH₂Cl₂, overnight

2: 96 percent / Bu₄NF, AcOH / tetrahydrofuran / 0.5 h

3: 81 percent / NaH (60percent in oil) / dimethylformamide / 2.5 h / Ambient temperature

With sodium hydroxide; sodium dithionite; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium hydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88016-9