2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

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Chemical Name:2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide
CAS No.:849670-50-4
Molecular Formula:C₂₆H₃₈F₃N₃O₄
Molecular Weight:513.601
Hs Code.:

Synonyms:2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

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Chemical Property of 2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

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Technology Process of 2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

There total 2 articles about 2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 769965-98-2
(S)-N₁-(4-trifluoromethoxy-phenyl)-propane-1,2-diamine

: 849671-52-9
2-(R)-(2-cyclohexyl-ethyl)-4-morpholin-4-yl-4-oxo-butyric acid

: 849670-50-4
2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 23 ℃;
DOI:10.1016/j.bmcl.2007.02.049

Reference yield:

: 769965-99-3
[1(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-carbamic acid benzyl ester

: 849670-50-4
2-(R)-(2-cyclohexyl-ethyl)-N-[1-(S)-methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;