Technology Process of Lys(ε-Boc)-Pro-Ser(O-t-Bu)-Tyr(O-t-Bu)-OAll
There total 9 articles about Lys(ε-Boc)-Pro-Ser(O-t-Bu)-Tyr(O-t-Bu)-OAll which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamine;
In
acetonitrile;
at 20 ℃;
for 0.5h;
DOI:10.1021/jo991523w
- Guidance literature:
-
Multi-step reaction with 6 steps
1: DCC / CH2Cl2 / 0 - 20 °C
2: 570 mg / DIPEA / dimethylformamide / 17 h / 0 - 20 °C
3: 194 g / BOP; DIPEA / CH2Cl2 / 72 h
4: Et2NH / acetonitrile / 0.5 h / 20 °C
5: 114 mg / BroP; DIPEA / CH2Cl2 / 3 h / 20 °C
6: Et2NH / acetonitrile / 0.5 h / 20 °C
With
bromo-tris-dimethylamino-phosphonium hexafluorophosphate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
1: Esterification / 2: Condensation / 3: Condensation / 4: Substitution / 5: Condensation / 6: Substitution;
DOI:10.1021/jo991523w
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Cs2CO3 / methanol / 2 h / 20 °C
1.2: 98 percent / dimethylformamide / 18 h / 20 °C
2.1: Et2NH / acetonitrile / 0.5 h / 20 °C
3.1: 194 g / BOP; DIPEA / CH2Cl2 / 72 h
4.1: Et2NH / acetonitrile / 0.5 h / 20 °C
5.1: 114 mg / BroP; DIPEA / CH2Cl2 / 3 h / 20 °C
6.1: Et2NH / acetonitrile / 0.5 h / 20 °C
With
bromo-tris-dimethylamino-phosphonium hexafluorophosphate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; diethylamine; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; acetonitrile;
1.1: Metallation / 1.2: Esterification / 2.1: Substitution / 3.1: Condensation / 4.1: Substitution / 5.1: Condensation / 6.1: Substitution;
DOI:10.1021/jo991523w
