4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester

Base Information

Chemical Name:4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester
CAS No.:918797-42-9
Molecular Formula:C₄₂H₄₆N₄O₆
Molecular Weight:702.85
Hs Code.:

Synonyms:4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester

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Chemical Property of 4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester

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Technology Process of 4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester

There total 5 articles about 4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 918797-42-9
4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

2: HCl / dioxane / 0.5 h / 20 °C

3: 142 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d

Reference yield:

: 2215-89-6
oxybis(benzoic acid)

: 918797-42-9
4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / Et₃N / dimethylformamide / 3 h / 60 °C

2: 142 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm061033d

Reference yield:

: 63-45-6
primaquine diphosphate

: 918797-42-9
4-(4-(((S)-1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

2: HCl / dioxane / 0.5 h / 20 °C

3: 142 mg / N-methylmorpholine; 1-hydroxybenzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆ / dimethylformamide

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm061033d