2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine

Base Information

Chemical Name:2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine
CAS No.:309967-60-0
Molecular Formula:C₄₇H₅₀N₅O₁₀PS
Molecular Weight:907.981
Hs Code.:

Synonyms:2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine

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Chemical Property of 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine

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Technology Process of 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine

There total 5 articles about 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 309967-56-4
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-4-N-benzoylcytidine

: 309967-60-0
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine

Guidance literature:: With pyridine; at 20 ℃; for 4h;
DOI:10.1021/jo991097e

Reference yield:

: 13089-48-0
N₄-benzoylcytidine

: 309967-60-0
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / AgNO₃

2: 1H-tetrazole / CH₂Cl₂ / 19 h / 20 °C

3: S₈ / CS₂; pyridine / 2 h / 20 °C

4: 3.29 g / HF*Py / pyridine / 0.17 h

5: 91 percent / pyridine / 4 h / 20 °C

With pyridine; 1H-tetrazole; sulfur; pyridine hydrogenfluoride; silver nitrate; In pyridine; carbon disulfide; dichloromethane; 1: Cyclization / 2: Substitution / 3: sulfurization / 4: desilylation / 5: tritylation;
DOI:10.1021/jo991097e

Reference yield:

: 137734-44-2
3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoylcytidine

: 309967-60-0
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-4-N-benzoylcytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-tetrazole / CH₂Cl₂ / 19 h / 20 °C

2: S₈ / CS₂; pyridine / 2 h / 20 °C

3: 3.29 g / HF*Py / pyridine / 0.17 h

4: 91 percent / pyridine / 4 h / 20 °C

With pyridine; 1H-tetrazole; sulfur; pyridine hydrogenfluoride; In pyridine; carbon disulfide; dichloromethane; 1: Substitution / 2: sulfurization / 3: desilylation / 4: tritylation;
DOI:10.1021/jo991097e