(5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Base Information

Chemical Name:(5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline
CAS No.:173787-61-6
Molecular Formula:C₁₈H₁₉NO
Molecular Weight:265.355
Hs Code.:

Synonyms:(5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

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Chemical Property of (5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

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Technology Process of (5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

There total 3 articles about (5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 173787-60-5
Isobutyric acid (1R,8S,9S)-10,10-dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-trien-8-yl ester

: 173787-61-6
(5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Guidance literature:: With sodium hydroxide; In methanol; for 1h; Heating;
DOI:10.1016/0957-4166(95)00381-9

Reference yield:

: (1R,9R)-10,10-Dimethyl-5-phenyl-6-aza-tricyclo[7.1.1.0^2,7]undeca-2⁽⁷⁾,3,5-triene 6-oxide

: 173787-61-6
(5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 8 h / 100 °C

2: 95 percent / aq. NaOH / methanol / 1 h / Heating

With sodium hydroxide; In methanol;
DOI:10.1016/0957-4166(95)00381-9

Reference yield:

: 173787-59-2
(-)-(1R,5R)-2,3-(2'-Phenyl-1'-azobenzo)-6,6-dimethylbicyclo[3.1.1]heptane

: 173787-61-6
(5R,7S,8S)-8-hydroxy-5,6,7,8-Tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: HOOAc / acetic acid / 24 h / 70 °C

2: 8 h / 100 °C

3: 95 percent / aq. NaOH / methanol / 1 h / Heating

With peracetic acid; sodium hydroxide; In methanol; acetic acid;
DOI:10.1016/0957-4166(95)00381-9