3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Base Information

Chemical Name:3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester
CAS No.:852534-85-1
Molecular Formula:C₂₄H₁₈N₂O₄S
Molecular Weight:430.484
Hs Code.:

Synonyms:3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Suppliers and Price of 3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

There total 3 articles about 3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 852534-83-9
3-(2-methoxycarbonyl-phenyl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid ethyl ester

: 106-45-6
para-thiocresol

: 852534-85-1
3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Guidance literature:: With trimethylaluminum; In hexane; dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2005.02.038

Reference yield:

: 852534-80-6
2-[2-(ethoxyoxalyl-amino)-benzoylamino]-benzoic acid methyl ester

: 852534-85-1
3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Et₃N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C

2: 91 percent / AlMe₃ / CH₂Cl₂; hexane / 0 - 20 °C

With chloro-trimethyl-silane; trimethylaluminum; triethylamine; In hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2005.02.038

Reference yield:

: 49854-16-2
methyl 2-(2-aminobenzoylamino)benzoate

: 852534-85-1
3,4-dihydro-4-oxo-3-[2-(methoxycarbonyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / pyridine / tetrahydrofuran / 0.25 h / 0 °C

2: 87 percent / Et₃N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C

3: 91 percent / AlMe₃ / CH₂Cl₂; hexane / 0 - 20 °C

With pyridine; chloro-trimethyl-silane; trimethylaluminum; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2005.02.038