((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

Base Information

Chemical Name:((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester
CAS No.:131352-67-5
Molecular Formula:C₁₅H₁₆N₂O₆
Molecular Weight:320.302
Hs Code.:

Synonyms:((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

Suppliers and Price of ((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

There total 8 articles about ((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 131352-54-0
((1S,5S)-3-Oxo-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

: 103-71-9
phenyl isocyanate

: 131352-67-5
((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

Guidance literature:: In tetrahydrofuran; 1) 0 deg C, 1 h, 2) r.t., 1 h, 3) 1 h;
DOI:10.1021/jo00003a066

Reference yield:

: 131352-62-0,131352-63-1,137993-48-7,137993-49-8
methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-hydroxybutyrate

: 131352-67-5
((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / CrO₃, pyridine / CH₂Cl₂ / Ambient temperature

2: H₂ / Pd-C / ethyl acetate / 1.17 h

3: 70 percent / tetrahydrofuran / 1) 0 deg C, 1 h, 2) r.t., 1 h, 3) 1 h

With pyridine; chromium(VI) oxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jo00003a066

Reference yield:

: 131352-56-2,131352-57-3,137993-44-3,137993-45-4
β-<(tert-butyldimethylsilyl)oxy>-δ-hydroxypimelic acid, methyl benzyl diester

: 131352-67-5
((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) H₂, 2) N-hydroxysuccinimide, dicyclohexylcarbodiimide / 1) 10percent Pd/C

2: 66 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 1) 45 min., -10 deg C, 2) 2 h, r.t.

3: 86 percent / HOAc, Bu₄N⁽¹⁺⁾F^(1-) / tetrahydrofuran / 18 h

4: 72 percent / CrO₃, pyridine / CH₂Cl₂ / Ambient temperature

5: H₂ / Pd-C / ethyl acetate / 1.17 h

6: 70 percent / tetrahydrofuran / 1) 0 deg C, 1 h, 2) r.t., 1 h, 3) 1 h

With pyridine; chromium(VI) oxide; 1-hydroxy-pyrrolidine-2,5-dione; tetrabutyl ammonium fluoride; hydrogen; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jo00003a066