[(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol

Base Information

Chemical Name:[(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol
CAS No.:201472-82-4
Molecular Formula:C₁₅H₂₀FNO
Molecular Weight:249.328
Hs Code.:

Synonyms:[(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol

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Chemical Property of [(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol

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Technology Process of [(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol

There total 4 articles about [(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157008-48-5
(1R)-N-methyl-2β-methoxycarbonyl-3α-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane

: 201472-82-4
[(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm970669p

Reference yield:

: 1493-23-8
(4-fluorophenyl)lithium

: 201472-82-4
[(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / diethyl ether; pentane / 3 h / -78 - -40 °C

2: 1.03 g / Ni₂B, 12N aq. HCl / a) RT, 2 h, b) reflux, 3 h

3: LiAlH₄ / diethyl ether / 2 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; nickel boride; In diethyl ether; pentane;
DOI:10.1021/jm970669p

Reference yield:

: (1R,5S)-2-(3'-methyl-1',2',4'-oxadiazol-5'-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene

: 201472-82-4
[(1R,2S,3R,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / diethyl ether; pentane / 3 h / -78 - -40 °C

2: 1.03 g / Ni₂B, 12N aq. HCl / a) RT, 2 h, b) reflux, 3 h

3: LiAlH₄ / diethyl ether / 2 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; nickel boride; In diethyl ether; pentane;
DOI:10.1021/jm970669p