3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane

Base Information

• Chemical Name: 3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane
• CAS No.: 132981-27-2
• Molecular Formula: C₁₆H₁₉NO₃S
• Molecular Weight: 305.398
• Mol file: 132981-27-2.mol

Synonyms:3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane

Chemical Property of 3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane

There total 4 articles about 3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

thiophosgene (463-71-8) + 3-<<(p-aminobenzoyl)oxy>methyl>-3-tert-butyloxetane (132981-26-1) → 3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane (132981-27-2)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; for 0.333333h; Ambient temperature;

DOI:10.1021/jm00109a002

Reference yield:

3-t-butyl-3-hydroxymethyl-oxetane (99250-47-2) → 3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane (132981-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 86 percent / H₂ / 10percent Pd/C / ethyl acetate / 0.67 h / 2585.7 Torr

3: 69 percent / aq. NaHCO₃ / CHCl₃ / 0.33 h / Ambient temperature

With pyridine; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In dichloromethane; chloroform; ethyl acetate;

DOI:10.1021/jm00109a002

Reference yield:

3-<<(p-nitrobenzoyl)oxy>methyl>-3-tert-butyloxetane (132981-25-0) → 3-<<(p-isothiocyanatobenzoyl)oxy>methyl>-3-tert-butyloxetane (132981-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / H₂ / 10percent Pd/C / ethyl acetate / 0.67 h / 2585.7 Torr

2: 69 percent / aq. NaHCO₃ / CHCl₃ / 0.33 h / Ambient temperature

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In chloroform; ethyl acetate;

DOI:10.1021/jm00109a002

upstream raw materials:

thiophosgene

3-<<(p-aminobenzoyl)oxy>methyl>-3-tert-butyloxetane

3-t-butyl-3-hydroxymethyl-oxetane

3-<<(p-nitrobenzoyl)oxy>methyl>-3-tert-butyloxetane

Downstream raw materials:

1-(p-isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo<2.2.2>octane