4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

Base Information

Chemical Name:4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol
CAS No.:440360-55-4
Molecular Formula:C₄₁H₄₂O₁₁S
Molecular Weight:742.844
Hs Code.:

Synonyms:4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

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Chemical Property of 4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

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Technology Process of 4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

There total 7 articles about 4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-24-7
acetic anhydride

: 440360-54-3
1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-tolyenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

: 440360-55-4
4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jo0111107

Reference yield:

: 354137-28-3
1,2-dideoxy-4,5:7,8-bis-O-(1-methylethylidene)-1-phenyl-D-glycero-D-galacto-oct-1-ynitol

: 440360-55-4
4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

2: 91 percent / aq. AcOH / 20 °C

3: 50 percent / pyridine; DMAP / 0 °C

4: 85 percent / pyridine / 20 °C

With pyridine; dmap; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jo0111107

Reference yield:

: 440360-41-8
4,5,7-tri-O-acetyl-1,2,8-trideoxy-8-iodo-3,6-bis-O-(phenylmethyl)-D-glycero-D-talo-oct-1-ynitol

: 440360-55-4
4,5,7-tri-O-acetyl-1,2-dideoxy-1-phenyl-3,6-bis-O-(phenylmethyl)-8-p-toluenesulfonyl-D-glycero-D-galacto-oct-1-ynitol

Guidance literature:: Multi-step reaction with 5 steps

1: 11 percent / Et₃B; Ph₃SnH / toluene / -78 °C

2: 68 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

3: 91 percent / aq. AcOH / 20 °C

4: 50 percent / pyridine; DMAP / 0 °C

5: 85 percent / pyridine / 20 °C

With pyridine; dmap; triethyl borane; triphenylstannane; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jo0111107