Technology Process of 2-<<<(4S,5S)-4-benzyl-2,2-dimethyl-5-oxazolidinyl>methyl>thio>acetic acid
There total 6 articles about 2-<<<(4S,5S)-4-benzyl-2,2-dimethyl-5-oxazolidinyl>methyl>thio>acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-methylmorpholine (NMM) / ethyl acetate / 0.17 h / -10 °C
2: diethyl ether / 3 h / Ambient temperature
3: 47percent aq. HBr / dioxane / 1 h / 0 °C
4: 76 percent / sodium borohydride / methanol / 1 h / 0 °C
5: 88 percent / p-toluenesulfonic acid / CH2Cl2 / 36 h / Ambient temperature
6: 1.) NaOMe, 2.) KI / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 36 h
With
4-methyl-morpholine; sodium tetrahydroborate; hydrogen bromide; sodium methylate; toluene-4-sulfonic acid; potassium iodide;
In
1,4-dioxane; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm00115a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 47percent aq. HBr / dioxane / 1 h / 0 °C
2: 76 percent / sodium borohydride / methanol / 1 h / 0 °C
3: 88 percent / p-toluenesulfonic acid / CH2Cl2 / 36 h / Ambient temperature
4: 1.) NaOMe, 2.) KI / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 36 h
With
sodium tetrahydroborate; hydrogen bromide; sodium methylate; toluene-4-sulfonic acid; potassium iodide;
In
1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm00115a016
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / sodium borohydride / methanol / 1 h / 0 °C
2: 88 percent / p-toluenesulfonic acid / CH2Cl2 / 36 h / Ambient temperature
3: 1.) NaOMe, 2.) KI / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 36 h
With
sodium tetrahydroborate; sodium methylate; toluene-4-sulfonic acid; potassium iodide;
In
methanol; dichloromethane;
DOI:10.1021/jm00115a016
