Technology Process of 9-(4-aminopiperidine-1-yl)-5-[3,5-bis(trifluoromethyl)benzyl]-6-oxo-7-phenyl-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine
There total 10 articles about 9-(4-aminopiperidine-1-yl)-5-[3,5-bis(trifluoromethyl)benzyl]-6-oxo-7-phenyl-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 5 h / -78 °C
1.2: 1 h / -78 - 20 °C
2.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 100 °C
2.2: 3 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 - 20 °C
4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water; toluene / 7 h / Heating / reflux
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C
6.1: trichlorophosphate / 1 h / Heating / reflux
7.1: 5 h / 140 °C
8.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C
With
hydrogenchloride; thionyl chloride; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 100 °C
1.2: 3 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 - 20 °C
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water; toluene / 7 h / Heating / reflux
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C
5.1: trichlorophosphate / 1 h / Heating / reflux
6.1: 5 h / 140 °C
7.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C
With
hydrogenchloride; thionyl chloride; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; toluene;
