(E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester

Base Information

Chemical Name:(E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester
CAS No.:307973-35-9
Molecular Formula:C₂₂H₁₉FO₃
Molecular Weight:350.389
Hs Code.:

Synonyms:(E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester

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Chemical Property of (E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester

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Technology Process of (E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester

There total 4 articles about (E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 13565-08-7
(E)-3-(4-fluorophenyl)acryloyl chloride

: 307973-30-4
2-(4-hydroxyphenylmethylene)cyclohexanone

: 307973-35-9
(E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester

Guidance literature:: With pyridine; In acetonitrile; Heating;
DOI:10.1021/jm000058o

Reference yield:

: 459-32-5
(E)-4-fluorocinnamic acid

: 307973-35-9
(E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Heating

2: 75 percent / pyridine / acetonitrile / Heating

With pyridine; thionyl chloride; In acetonitrile; 1: Chlorination / 2: Acylation;
DOI:10.1021/jm000058o

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 307973-35-9
(E)-3-(4-Fluoro-phenyl)-acrylic acid 4-[2-oxo-cyclohex-(E)-ylidenemethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / aq. NaOH / 36 h / 20 °C

2: 75 percent / pyridine / acetonitrile / Heating

With pyridine; sodium hydroxide; In acetonitrile; 1: Substitution / 2: Acylation;
DOI:10.1021/jm000058o