4-Ethynyl-2-fluorobenzenamine

Base Information

Chemical Name:4-Ethynyl-2-fluorobenzenamine
CAS No.:1008112-39-7
Molecular Formula:C₈H₆FN
Molecular Weight:135.141
Hs Code.:
Mol file:1008112-39-7.mol

Synonyms:4-ethynyl-2-fluoroaniline

Suppliers and Price of 4-Ethynyl-2-fluorobenzenamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-AMINO-3-FLUOROPHENYLACETYLENE 95.00%
5MG
$ 501.67

Activate Scientific
4-Ethynyl-2-fluorobenzenamine 95%
1 g
$ 312.00

Activate Scientific
4-Ethynyl-2-fluorobenzenamine 95%
5 g
$ 897.00

Acrotein
4-Ethynyl-2-fluorobenzenamine 95%
5g
$ 660.00

Acrotein
4-Ethynyl-2-fluorobenzenamine 95%
0.5g
$ 146.67

Total 8 raw suppliers

Chemical Property of 4-Ethynyl-2-fluorobenzenamine

Chemical Property:

Boiling Point:213.6±30.0 °C(Predicted)
PKA:1.71±0.10(Predicted)
Density:1.16±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4-AMINO-3-FLUOROPHENYLACETYLENE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Ethynyl-2-fluorobenzenamine

There total 2 articles about 4-Ethynyl-2-fluorobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 518342-58-0
2-fluoro-4-((trimethylsilyl)ethynyl)aniline

: 1008112-39-7
4-ethynyl-2-fluoroaniline

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 0.5h;
DOI:10.1021/acsmedchemlett.6b00057

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1008112-39-7
4-ethynyl-2-fluoroaniline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere

2: potassium carbonate; methanol / 0.5 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/acsmedchemlett.6b00057

Reference yield: 45.0%

: 6746-94-7
Cyclopropylacetylene

: 1008112-39-7
4-ethynyl-2-fluoroaniline

: 4-(cyclopropylbuta-1,3-diyn-1-yl)-2-fluoroaniline

Guidance literature:: With copper(l) iodide; nickel(II) chloride hexahydrate; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/acsmedchemlett.6b00057