2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel

Base Information

• Chemical Name: 2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel
• CAS No.: 901778-62-9
• Molecular Formula: C₆₈H₇₅N₃O₂₇
• Molecular Weight: 1366.35
• Mol file: 901778-62-9.mol

Synonyms:2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel

Chemical Property of 2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel

There total 1 articles about 2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2'-O-{N-methyl-N-[4-(allyl (2,3,4-tri-O-tert-butyldimethylsilyl-β-D-glucopyranosid)uronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel → 2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel (901778-62-9)

Guidance literature:

With pyridine; pyridine hydrogenfluoride; at 20 ℃; for 26h;

DOI:10.1016/j.bmc.2006.03.002

Reference yield: 81.0%

2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel (901778-62-9) → 2'-O-{N-methyl-N-[4-(β-D-glucopyranosiduronate)-3-aminobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel

Guidance literature:

With formic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2006.03.002

Reference yield: 80.0%

2'-O-{N-methyl-N-[4-(allyl β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel (901778-62-9) → 2'-O-{N-methyl-N-[4-(β-D-glucopyranosiduronate)-3-nitrobenzyloxycarbonyl]-2-aminoethyl}oxycarbonylpaclitaxel

Guidance literature:

With acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2006.03.002