1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione

Base Information

Chemical Name:1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione
CAS No.:1416915-49-5
Molecular Formula:C₁₆H₁₆N₄OS
Molecular Weight:312.395
Hs Code.:

Synonyms:1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione

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Technology Process of 1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione

There total 3 articles about 1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1416915-42-8
1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-one

: 1416915-49-5
1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione

Guidance literature:: With tetraphosphorus decasulfide; In neat (no solvent); at 175 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm401225q

Reference yield:

: 1416915-36-0
1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-benzyloxypyridin-2-one

: 1416915-49-5
1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / dichloromethane; ethyl acetate; methanol / 5 h

2: tetraphosphorus decasulfide / neat (no solvent) / 2 h / 175 °C / Inert atmosphere

With tetraphosphorus decasulfide; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm401225q

Reference yield:

: 499237-99-9
1-(3-azidopropyl)-3-benzyloxypyridin-2-one

: 1416915-49-5
1-(3-(4-phenyl-1,2,3-1H-triazole-1-yl)propyl)-3-hydroxypyridin-2-thione

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / dichloromethane; ethyl acetate; methanol / 5 h

3: tetraphosphorus decasulfide / neat (no solvent) / 2 h / 175 °C / Inert atmosphere

With copper(l) iodide; tetraphosphorus decasulfide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1: |Huisgen Cycloaddition;
DOI:10.1021/jm401225q