5-(3-(4-Chloro-phenyl)-isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:5-(3-(4-Chloro-phenyl)-isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
CAS No.:133040-30-9
Molecular Formula:C₁₈H₁₆ClN₃O₆
Molecular Weight:405.795
Hs Code.:
UNII:VP2MJB57WA
ChEMBL ID:CHEMBL2368960
DSSTox Substance ID:DTXSID60927906
Nikkaji Number:J412.608D
Wikidata:Q82902615

Synonyms:133040-30-9;VP2MJB57WA;5-(3-(4-Chloro-phenyl)-isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione;5-(3-(4-Chlorophenyl)-1,2-oxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-(3-(4-Chlorophenyl)isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;5-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione;UNII-VP2MJB57WA;CHEMBL2368960;DTXSID60927906;URIDINE, 5-(3-(4-CHLOROPHENYL)-5-ISOXAZOLYL)-2'-DEOXY-;5-[3-(4-Chlorophenyl)-1,2-oxazol-5-yl]-1-(2-deoxypentofuranosyl)-4-hydroxypyrimidin-2(1H)-one;5-[3-(4-chlorophenyl)isoxazol-5-yl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione

Suppliers and Price of 5-(3-(4-Chloro-phenyl)-isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 5-(3-(4-Chloro-phenyl)-isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:405.0727629
Heavy Atom Count:28
Complexity:653

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C=C(C(=O)NC2=O)C3=CC(=NO3)C4=CC=C(C=C4)Cl)CO)O
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C3=CC(=NO3)C4=CC=C(C=C4)Cl)CO)O

Technology Process of 5-(3-(4-Chloro-phenyl)-isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

There total 3 articles about 5-(3-(4-Chloro-phenyl)-isoxazol-5-yl)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133040-27-4
C₃₄H₂₈ClN₃O₈

: 133040-30-9
5-<3-(p-chlorophenyl)isoxazol-5-yl>-2'-deoxyuridine

Guidance literature:: With sodium methylate; In methanol; for 2h; Yield given;
DOI:10.1021/jm00110a003

Reference yield:

: 69075-43-0
5-Ethynyl-3',5'-di-O-p-toluyl-2'-deoxyuridine

: 133040-30-9
5-<3-(p-chlorophenyl)isoxazol-5-yl>-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 2 h / -20 °C

2: NaOCH₃ / methanol / 2 h

With sodium methylate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm00110a003

Reference yield:

: 28123-63-9
4-chlorobenzohydroximoyl chloride

: 133040-30-9
5-<3-(p-chlorophenyl)isoxazol-5-yl>-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 2 h / -20 °C

2: NaOCH₃ / methanol / 2 h

With sodium methylate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm00110a003