3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

Base Information

Chemical Name:3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione
CAS No.:1323404-89-2
Molecular Formula:C₂₁H₂₀N₂O₅
Molecular Weight:380.4
Hs Code.:

Synonyms:3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

Suppliers and Price of 3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

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Technology Process of 3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

There total 19 articles about 3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4-carbamoyl-2-[4-(4-hydroxymethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-butyric acid tert-butyl ester

: 1323404-89-2
3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 7h;

Reference yield:

: 3-[4-[[4-[[tert-butyl(dimethyl)silyl]oxymethyl]phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

: 1323404-89-2
3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

Guidance literature:: With sulfuric acid; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b01928

Reference yield:

: 125320-20-9
4-(bromomethyl)-t-butyldimethylsilyloxymethylbenzene

: 1323404-89-2
3-[4-[[4-(hydroxymethyl)phenyl]methoxy]-1-oxoisoindolin-2-yl]piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3: sulfuric acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With sulfuric acid; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.9b01928