{4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate

Base Information

Chemical Name:{4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate
CAS No.:1381767-21-0
Molecular Formula:C₄H₄O₄*C₁₉H₁₈N₂O
Molecular Weight:406.438
Hs Code.:

Synonyms:{4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate

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Chemical Property of {4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate

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Technology Process of {4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate

There total 9 articles about {4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1381767-18-5
tert-butyl [(1-benzoyl-5-phenyl-1H-pyrrol-3-yl)methyl]-methylcarbamate

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1381767-21-0
{4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate

Guidance literature:: tert-butyl [(1-benzoyl-5-phenyl-1H-pyrrol-3-yl)methyl]-methylcarbamate; With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 4h;

With sodium carbonate;

(2E)-but-2-enedioic acid; In methanol; ethyl acetate;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 881673-95-6
(5-phenyl-1H-pyrrol-3-yl)methanol

: 1381767-21-0
{4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C / Molecular sieve

2: methanol / 0.5 h / 20 °C

3: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

4: acetonitrile / 1.5 h / 20 °C

5: 15-crown-5; sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

6: hydrogenchloride / methanol; ethyl acetate / 4 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; tetrapropylammonium perruthennate; 15-crown-5; sodium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: C₁₂H₁₄N₂

: 1381767-21-0
{4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}-(phenyl)methanone fumarate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 1.5 h / 20 °C

2: 15-crown-5; sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

3: hydrogenchloride / methanol; ethyl acetate / 4 h / 20 °C

With hydrogenchloride; 15-crown-5; sodium hydride; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.014