2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

Base Information

Chemical Name:2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole
CAS No.:1370431-83-6
Molecular Formula:C₂₇H₂₉N₃OS
Molecular Weight:443.613
Hs Code.:

Synonyms:2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

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Chemical Property of 2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

Chemical Property:

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Technology Process of 2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

There total 6 articles about 2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370428-08-2
2-[(3-bromophenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

: 100-53-8
phenylmethanethiol

: 1370431-83-6
2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 120 ℃; for 24h; Sealed tube; Inert atmosphere;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1370431-83-6
2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

1.2: 3 h / Dean-Stark apparatus; Reflux

1.3: pH 1

2.1: hydrogenchloride / water / 4 h / Reflux

3.1: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 120 h / Reflux; Dean-Stark apparatus

4.1: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 120 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 49839-81-8
3-bromomandelic acid

: 1370431-83-6
2-[(3-benzylsulfanylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 4 h / Reflux

2: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 120 h / Reflux; Dean-Stark apparatus

3: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 120 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;