Technology Process of D-valyl-leucyl-lysine p-nitroanilide dihydrobromide
There total 9 articles about D-valyl-leucyl-lysine p-nitroanilide dihydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen bromide; trifluoroacetic acid;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / 1.0N NaOH / H2O; dioxane / 24 h / Ambient temperature
2: 86 percent / ethyl acetate; dioxane / 1) 0 deg C, 1h, 2) RT, 5h
3: 68 percent / 4-ethylmorpholino / dioxane / 24 h / Ambient temperature
4: 100 percent / CF3COOH, HBr / 1 h / 0 °C
With
N-ethylmorpholine;; sodium hydroxide; hydrogen bromide; trifluoroacetic acid;
In
1,4-dioxane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 44 percent / Boc2O, pyridine / dioxane / 18 h / Ambient temperature
2: CH2Cl2 / 1 h / Ambient temperature
3: 68 percent / 4-ethylmorpholino / dioxane / 24 h / Ambient temperature
4: 100 percent / CF3COOH, HBr / 1 h / 0 °C
With
N-ethylmorpholine;; pyridine; di-tert-butyl dicarbonate; hydrogen bromide; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane;
