(S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal

Base Information

Chemical Name:(S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal
CAS No.:903516-23-4
Molecular Formula:C₂₄H₄₅NO₅SSi
Molecular Weight:487.777
Hs Code.:

Synonyms:(S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal

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Chemical Property of (S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal

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Technology Process of (S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal

There total 4 articles about (S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 316363-73-2
(S)-O-(tert-butyldimethylsilyl)-N-(4-methylbenzenesulfonyl)-leucinol

: 96994-77-3
3-iodopropionaldehyde dimethylacetal

: 903516-23-4
(S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃; for 144h;
DOI:10.1021/jo060495w

Reference yield:

: 7533-40-6,14438-11-0
(S)-2-amino-4-methylpentan-1-ol

: 903516-23-4
(S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP; triethylamine / CH₂Cl₂ / 0 - 25 °C

2: 78 percent / imidazole / dimethylformamide / 0 - 25 °C

3: 80 percent / cesium carbonate / acetonitrile / 144 h / 20 °C

With 1H-imidazole; dmap; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo060495w

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 903516-23-4
(S)-4-aza-5-iso-butyl-6-(tert-butyldimethylsilanyloxy)-4-(p-toluenesulfonyl)hexanal dimethyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP; triethylamine / CH₂Cl₂ / 0 - 25 °C

2: 78 percent / imidazole / dimethylformamide / 0 - 25 °C

3: 80 percent / cesium carbonate / acetonitrile / 144 h / 20 °C

With 1H-imidazole; dmap; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo060495w