Technology Process of N-Butyl-5-nitro-2-(2-propynyloxy)benzamide
There total 3 articles about N-Butyl-5-nitro-2-(2-propynyloxy)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
tetrabutylammomium bromide;
In
toluene;
at 40 ℃;
for 0.5h;
Product distribution;
other catalysts, other NaOH concentrations, other solvents and reaction time;
DOI:10.1055/s-1982-30077
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
2.1: sodium hydride / 1,4-dioxane; mineral oil / 2 h / 70 °C / Cooling with ice; Inert atmosphere
2.2: 4 h / 70 °C / Inert atmosphere
With
sodium hydride; triethylamine;
In
1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.06.026
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.5 h / 0 °C
2.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
3.1: sodium hydride / 1,4-dioxane; mineral oil / 2 h / 70 °C / Cooling with ice; Inert atmosphere
3.2: 4 h / 70 °C / Inert atmosphere
With
sodium hydride; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.06.026
