4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene

Base Information

• Chemical Name: 4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene
• CAS No.: 917774-56-2
• Molecular Formula: C₂₈H₂₁BF₂N₂
• Molecular Weight: 434.296
• Mol file: 917774-56-2.mol

Synonyms:4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene

Chemical Property of 4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene

There total 3 articles about 4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3,7-dibromo-5,5-difluoro-10-(p-tolyl)-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine (1219941-27-1) + phenylboronic acid (98-80-6) → 4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene (917774-56-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; toluene; at 80 ℃; for 1h;

DOI:10.1002/ejoc.201402599

Reference yield: 56.0%

3,5-dichloro-4,4-difluoro-4-bora-8-(4-methylphenyl)-3a,4a-diaza-s-indacene + phenylzinc(II) bromide (38111-44-3) → 4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene (917774-56-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride;

DOI:10.1039/c4ra00651h

Reference yield:

5-(4-methylphenyl)dipyrromethane (147804-55-5) → 4,4-difluoro-3,5-diphenyl-8-(4-tolyl)-4-bora-3a,4adiaza-s-indacene (917774-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; toluene; water / 1 h / 80 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; toluene; 2: |Suzuki Coupling;

DOI:10.1002/ejoc.201402599

upstream raw materials:

phenylzinc(II) bromide

5-(4-methylphenyl)dipyrromethane

3,7-dibromo-5,5-difluoro-10-(p-tolyl)-5H-4λ⁴,5λ⁴-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine

phenylboronic acid