[(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-acetaldehyde

Base Information

• Chemical Name: [(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-acetaldehyde
• CAS No.: 190850-92-1
• Molecular Formula: C₁₉H₃₅O₂P
• Molecular Weight: 326.459

Synonyms:[(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-acetaldehyde

Chemical Property of [(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-acetaldehyde

Chemical Property:

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Technology Process of [(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-acetaldehyde

There total 3 articles about [(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,4S)-4-Allyl-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-2,2,3,3-tetramethyl-phosphetane 1-oxide (190850-90-9) → [(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ5-phosphetan-2-yl]-acetaldehyde (190850-92-1)

Guidance literature:

With dimethylsulfide; ozone; Multistep reaction; 1.) CH₂Cl₂, -78 deg C, 0.5 h;

DOI:10.1055/s-1998-2169

Reference yield:

3-[(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ5-phosphetan-2-ylmethyl]-[1,2,4]trioxolane → [(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ5-phosphetan-2-yl]-acetaldehyde (190850-92-1)

Guidance literature:

With dimethylsulfide; at -78 - 25 ℃; for 0.5h; Yield given;

DOI:10.1016/S0022-328X(96)06563-1

Reference yield:

(P(R)) 1-menthyl-3,3,4,4-tetramethylphosphetane oxide (153985-32-1) → [(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ5-phosphetan-2-yl]-acetaldehyde (190850-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

2: O₃ / CH₂Cl₂ / -78 °C

3: dimethylsulfide / 0.5 h / -78 - 25 °C

With n-butyllithium; dimethylsulfide; ozone; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/S0022-328X(96)06563-1

upstream raw materials:

(1S,4S)-4-Allyl-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-2,2,3,3-tetramethyl-phosphetane 1-oxide

(P(R)) 1-menthyl-3,3,4,4-tetramethylphosphetane oxide

Downstream raw materials:

(4R,5R)-2-[(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-ylmethyl]-4,5-diphenyl-[1,3]dioxolane

2-[(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-ethanol

2-[(1R,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-phosphetan-2-yl]-ethanol

(4S,5S)-2-[(1S,2S)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-ylmethyl]-4,5-diphenyl-[1,3]dioxolane

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