{2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol

Base Information

• Chemical Name: {2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol
• CAS No.: 636566-58-0
• Molecular Formula: C₂₇H₄₆O₂S₂Si
• Molecular Weight: 494.879
• Mol file: 636566-58-0.mol

Synonyms:{2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol

Chemical Property of {2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol

There total 1 articles about {2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-cyclohexene-1-carboxaldehyde (1192-88-7) + tert-Butyl-[(3R,5R)-5-isopropenyl-2-methyl-3-(2-tributylstannanyl-[1,3]dithian-2-yl)-cyclohex-1-enyloxy]-dimethyl-silane → {2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol (636566-58-0)

Guidance literature:

tert-Butyl-[(3R,5R)-5-isopropenyl-2-methyl-3-(2-tributylstannanyl-[1,3]dithian-2-yl)-cyclohex-1-enyloxy]-dimethyl-silane; With n-butyllithium; In tetrahydrofuran; hexane; at -100 ℃; for 0.5h;

1-cyclohexene-1-carboxaldehyde; In tetrahydrofuran; hexane; at -100 - 0 ℃;

DOI:10.1139/v03-119

Reference yield: 79.0%

acetic anhydride (108-24-7) + {2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol (636566-58-0) → Acetic acid {2-[(1R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methyl ester (636566-59-1)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 4h;

DOI:10.1139/v03-119

Reference yield:

{2-[(1R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methanol (636566-58-0) → (2S,3R,5R)-3-(3-Cyclohex-1-enyl-6,7-dihydro-5H-[1,4]dithiepin-2-yl)-5-isopropenyl-2-methyl-cyclohexanone

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / DMAP; pyridine / 4 h / 20 °C

2: 46 percent / p-TsOH*H₂O / benzene / 16 h / Heating

With pyridine; dmap; toluene-4-sulfonic acid; In benzene;

DOI:10.1139/v03-119

upstream raw materials:

1-cyclohexene-1-carboxaldehyde

Downstream raw materials:

Acetic acid {2-[(1R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-isopropenyl-2-methyl-cyclohex-2-enyl]-[1,3]dithian-2-yl}-cyclohex-1-enyl-methyl ester

C₂₁H₃₀OS₂