3'-DEOXY-3'-IODOTHYMIDINE

Base Information

• Chemical Name: 3'-DEOXY-3'-IODOTHYMIDINE
• CAS No.: 14260-82-3
• Molecular Formula: C₁₀H₁₃IN₂O₄
• Molecular Weight: 352.129
• Mol file: 14260-82-3.mol

Synonyms:3'-Deoxy-3'-iodothymidine

Chemical Property of 3'-DEOXY-3'-IODOTHYMIDINE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 84.32000
• Density: 1.91g/cm³
• LogP: -0.07160

Purity/Quality:

97% ^*data from raw suppliers

3'-Deoxy-3'-iodothymidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-DEOXY-3'-IODOTHYMIDINE

There total 4 articles about 3'-DEOXY-3'-IODOTHYMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3'-iodo-2',3'-dideoxy-5'-O-trityl-β-D-erythro-pentofuranosyl)thymine (25442-44-8) → 3'-deoxy-3'-iodothymidine (14260-82-3)

Guidance literature:

With water; acetic acid; at 90 ℃; for 0.5h;

DOI:10.1021/jm100165w

Reference yield:

1-(3-iodo-O5-trityl-β-D-threo-2,3-dideoxy-pentofuranosyl)-5-methyl-1H-pyrimidine-2,4-dione (66503-48-8) → 1-((2R)-5c-hydroxymethyl-4c-iodo-tetrahydro-[2r]furyl)-5-methyl-1H-pyrimidine-2,4-dione (14260-82-3)

Guidance literature:

With acetic acid;

DOI:10.1039/jr9550000816

Reference yield:

→ 3'-Deoxy-3'-iod-thymidin (14260-82-3)

Guidance literature:

5'-O-Acetyl-3'-deoxy-3'-iod-thymidin, milde alkalische Hydrolyse;

DOI:10.1021/ja01064a055

upstream raw materials:

1-(3-iodo-O⁵-trityl-β-D-threo-2,3-dideoxy-pentofuranosyl)-5-methyl-1H-pyrimidine-2,4-dione

1-(3'-iodo-2',3'-dideoxy-5'-O-trityl-β-D-erythro-pentofuranosyl)thymine

Downstream raw materials:

3'-Deoxythymidine